| Synthesis is
a high performance, general-purpose object oriented simulator
for modeling large collections of cells. It can simulate
systems consisting of a few complex cells or large-scale networks
of millions of interconnected elements with a high degree of
efficiency. The elements may represent anything from atoms
and molecules to larger structures such as cells and groups of
neurons. |
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Synthesis provides
a complete simulation environment, including: a computation server
capable of parallel and distributed computation, a graphical user-interface
for interactive visualization and manipulation, a scripting language
for automating parameter searches and experiments, an interactive command-line
environment for controlling the simulation, data agents for data-gathering
and analysis, a library of standard neuron, synapse and connection
pattern models. The simulation server is multithreaded for multiprocessor
computation and capable of distributing a simulation across multiple
networked computers.
The simulator can
model any complex system such as slime mold (dictyostelium discoideum)
aggregation behavior, heart tissue dynamics, intestine tissue motility,
the "Game of Life" cellular automata or even a large-scale
model of the mammalian visual thalamocortical system. In fact, anything
that can be characterized as a collection of individual elements with
internal states that might be modified by interactions can be modeled
with this simulator. Synthesis allows the user to interact fully with
a simulation, visualizing all variables - at different levels and time
scales - while observing all network interactions and controlling all
parameters in real-time throughout the course of a simulation.
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01-mar-08 I am currently working with the Blue Brain Project.
25-sep-07 The
new website for the Blue Brain Project is online.
28-sep-05 The
new website for the Center for Sleep and Consciousness is online.
30-apr-05 New
movies to accompany recent publications
have been posted.
23-mar-05
Modeling the effects of transcranial magnetic stimulation
on cortical
circuits. Simulating
TMS (transcranial magnetic stimulation) in a large-scale thalamocortical
model (new
paper is out).
10-nov-04
Modeling sleep and wakefulness in the thalamortical system. Read
all about the latest research in the generation of sleep rhythms
in large-scale thalamocortical circuitry at the Journal
of Neurophysiology.
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